Nursing MSN & DNP

| 11 September 2022

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Nurse Practitioner vs. Physician Assistant: Key Differences

Nurse Practitioner vs Physical Assitant-USAHS

Nurse practitioners and physician assistants are advanced healthcare practitioners with similar responsibilities, such as diagnosing illnesses and prescribing medications. However, their training and paths toward certification differ in significant ways. This blog post unpacks the key differences between NPs and PAs to help you determine which career path best aligns with your goals.

What Is a Nurse Practitioner?

A nurse practitioner (NP) is a licensed clinician who provides comprehensive healthcare to patients of all ages. An NP can work in virtually any healthcare setting, diagnosing patient conditions and prescribing medications. As of October 2022, nurse practitioners have full practice authority in 27 states, meaning that they can practice independently without the supervision of a physician.

The key responsibilities of a nurse practitioner include:

  • Diagnosing and treating acute and chronic conditions 
  • Prescribing medications, therapies, and other treatments
  • General patient care 
  • Performing and interpreting diagnostic tests (e.g., x-rays, lab work)
  • Educating patients about healthy lifestyle choices and disease prevention
  • Counseling patients about their health care plan
  • Other specialty-specific responsibilities

What Is a Physician Assistant?

A physician assistant (PA) is an advanced practice provider with an MSPAS degree who is licensed to provide many of the same clinical services as physicians when working in primary care settings. These services include performing physical exams, diagnosing and treating illnesses, and prescribing medications. ((Physician Assistant Education Association (PAEA), “What is a PA?”:   

The key responsibilities of a physician assistant include: ((American Academy of PAs (AAPA), “What is a PA?”:  

  • Taking medical histories
  • Ordering and interpreting lab tests and diagnostic tests
  • Performing physical exams
  • Diagnosing and treating illness 
  • Assisting in surgery
  • Educating patients about their treatment plan

NP vs. PA: Key Differences

The two most fundamental differences between NPs and PAs are the training they receive and the environments where they work. Nurse practitioners are trained in the advanced practice of nursing, where they focus on a specialized role, such as that of neonatal nurse practitioner. Physician assistants, on the other hand, are educated in general medicine; their training follows the medical model and covers all foundational aspects of medicine and specialties.


Educational Differences

Both nurse practitioners and physician assistants are required to earn a graduate degree, complete a rigorous schedule of clinical training, and acquire certifications. The differences lie in the type of training and certification requirements.

To become a nurse practitioner, you’ll need to complete the following: ((Nursing License Map, “How to Become a Nurse Practitioner,” July 2020:

  1. Earn your Bachelor of Science in Nursing (BSN) degree: A full-time BSN program typically takes four years to complete.
  2. Pass the NCLEX-RN: Passing this examination is required to practice as a registered nurse (RN) in your state. Once you pass the exam, you will receive your RN license.
  3. Earn a graduate degree: You will need either a Master of Science in Nursing (MSN) or a Doctor of Nursing Practice (DNP) with a nurse practitioner role specialty, such as Family Nurse Practitioner (FNP). In addition to coursework, NP programs typically include a clinical practicum of 500-650 hours under the supervision of a preceptor.
  4. Become a Certified Nurse Practitioner (CNP): You must take a national certification exam through one of the five national certification boards to become licensed as a nurse practitioner.
  5. Option to Recertify: For certification renewal, nurse practitioners must take 100 hours of continuing education and 1,000 clinical hours every five years.

To become a physician assistant, you’ll need to complete the following: ((National Commission on Certification of Physician Assistants (NCCPA), “Certified PAs: Improving health, saving lives, making a difference,” 2020: 

  1. Earn your master’s degree: You must graduate from an accredited PA program—typically a Master of Science in Physician Assistant Studies. You must also complete at least 2,000 hours of supervised clinical practice in various medical and surgical settings before graduation. 
  2. Pass the Physician Assistant National Certifying Examination (PANCE): Once you pass the PANCE exam, administered by the National Commission on Certification of Physician Assistants (NCCPA), you can receive your state license. 
  3. Maintain national certification: PAs must complete 100 hours of continuing medical education (CME) every two years. They are required to take a recertification exam every 6 to 10 years.
Work Environment Differences

Nurse practitioners and physician assistants work in primary, acute, and specialty care across a wide range of healthcare settings, including medical offices, hospitals, nursing homes, VA facilities, correctional institutions, and community clinics. 

Although PAs can serve as primary care providers, they are typically required to work under the direct supervision of a physician or surgeon. PAs’ scope of practice varies from state to state and is determined through state licensing requirements.

NPs must work under the supervision of a physician in 11 states. However, in 27 states and two U.S. territories, nurse practitioners can operate their own practice with full autonomy. (The remaining 16 states and U.S. territories have regulations that are somewhere in between.)

Specialization Differences

There are also legal distinctions between nurse practitioners and physician assistants. NPs can work across various nursing specialties, earning certifications for the specialties that require it. If an NP desires to switch specialty certifications, such as from neonatal to family nurse practitioner, they need formal education and licensure for that new role. As for PAs, once licensed, they can switch specialties without the need for a new certification or additional job training. ((Ryanne Coulson, “PA vs. NP: A Simple Explanation of the Fundamental Differences,” Be a Physician Assistant, May 2, 2017:   

Four common nurse practitioner roles graphic

NP vs. PA Career Outlook

Employment for both nurse practitioners and physician assistants is projected to grow over the next decade at faster rates than the average for other occupations. 

The U.S. Bureau of Labor Statistics predicts a 40 percent growth for NP roles and a 28 percent growth for PA roles  between 2021 and 2031. Also, U.S. News & World Report ranks these professions as the top two roles in 2022: nurse practitioner sits at #1 and physician assistant at #2 in the publication’s 2022 Best Healthcare Jobs list.

PA vs NP Salary

As of 2021, the median salary of a nurse practitioner is $123,780, while the median salary of a physician assistant is $121,530. Based on this BLS estimate, the nurse practitioner salary is slightly higher than the physician assistant salary, but not by much.

How to Choose the Right Career Path 

Cartoon graduate with two picture thought bubbles graphic

Comparing the educational requirements, work environments, and scope of practice can help you make career decisions. For example, NPs spend more time providing bedside care for hospitalized patients. Physician assistants, on the other hand, may take up a surgical specialty. ((, “Nurse Practitioner or Physician Assistant: Difference in Salary and Benefits,” September 5, 2019: 

Resources for Nurse Practitioners

The following organizations give nurse practitioners access to professional development opportunities, events, and other benefits:

Resources for Physician Assistants

Should you pursue a career as a physician assistant, these organizations will give you a chance to participate in seminars, networking events, and professional development opportunities:

Whether you decide to explore a career as an NP or PA, it’s encouraging to know that the demand for both is increasing within the healthcare field. Both are rewarding roles that can help patients live healthier and longer lives.    

The University of St. Augustine for Health Sciences (USAHS) offers Master of Science in Nursing (MSN), Doctor of Nursing Practice (DNP), and Post-Graduate Nursing Certificates designed for working nurses. Our degrees are offered online, with optional on-campus immersions.* Role specialties include Family Nurse Practitioner (FNP), Psychiatric Mental Health Nurse Practitioner (PMHNP), Nurse Educator,** and Nurse Executive. The MSN has several options to accelerate your time to degree completion. Earn your advanced nursing degree while keeping your work and life in balance.

*The FNP and PMHNP role specialties each include one required hands-on clinical intensive as part of the curriculum.

**The Nurse Educator role specialty, available only for the MSN and Post-Graduate Nursing Certificate programs, is not currently enrolling students.




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